HLA-B*57:01 Detection Kit

Real-time
PCR

CE-IVD

-Fast and Easy to use with qPCR technology.

-Easy screening of patients for the presence of HLA-B*57:01 before starting abacavir treatment.

-Compatible with FAM and VIC/HEX dual color real-time PCR instruments.

-Automatic analysis with geneMAP viewer (for CFX96).

INTENDED USE

The geneMAP™ HLA-B*57:01 Detection Kit is a fast and accurate real-time PCR test for detection of the HLA-B57:01 allele, a specific variant of the human leukocyte antigen B (HLA-B) gene that is strongly associated with abacavir hypersensitivity.

Abacavir is a nucleoside reverse transcriptase inhibitor used for combination antiretroviral therapy for treating human immunodeficiency virus (HIV) infection. An adverse effect from abacavir is a treatment-limiting hypersensitivity reaction, which can be severe and potentially life-threatening. Abacavir-induced hypersensitivity reaction has been associated with the presence of the major histocompatibility complex class I allele HLA-B*57:01. A screening test for the HLA-B*57:01 allele can assist clinicians to identify patients who are at risk of developing a hypersensitivity reaction to abacavir.