Celiac (DQ2, DQ8, DR4) Detection Kit

Real-time
PCR

CE-IVD

-Accurate results with Allele Spesific PCR technology

-Compatible with all real-time PCR instruments capable of melting curve analysis.

INTENDED USE

The geneMAP™ Celiac (DQ2, DQ8, DR4) Detection Kit can detect HLA-DQ2, HLA-DQ8 Heterodimers and HLA-DR4 Allele in Human Genomic DNA. Celiac disease is a common, familial, autoimmune gastrointestinal disease. It is caused by sensitivity to the dietary protein gluten, which is present in wheat, rye, and barley. Celiac disease has a strong genetic association with human leukocyte antigens (HLA). The primary susceptibility allele for Celiac disease is HLA-DQ2 which is composed of HLA-DQA1*05 and DQB1*02, rest of the cases is related to HLA-DQ8 that is composed of HLA-DQA1*03 DQB1*03:02 that is associated in haplotype with HLA-DR4 allele