HLA-B molecules are cell surface proteins that play an important role in immunity. The frequency of the HLA-B27 variant is about 8% in the general Caucasian population, whereas it is found in over 90% of patients suffering from ankylosing spondylitis (AS).
It was diagnosed in 1937 by Hulusi Behçet, a Turkish doctor, and is therefore referred to as Behçet’s Disease or Behçet’s Syndrome in the international literature.
Celiac disease is a common, familial, autoimmune gastrointestinal disease. It is caused by sensitivity to the dietary protein gluten, which is present in wheat, rye, and barley.