geneMAP™ BCR-ABL1 p190(mbcr) Detection Kit (BCR190-RT48)

FEATURES

  • Superior Analytical Sensitivity (Log4 Reduction)
  • Fast and Easy to Use with One Step RT-qPCR Technology
  • Accurate Relative Quantitation with Multiplex PCR (Fusion Transcripts/ABL1)
  • Compatible with FAM and VIC/HEX Dual Color Real-Time PCR Instruments
  • CE-IVD

Leukemia is one of the most common cancer types worldwide, presenting 250,000 cases annually. Leukemia is described as a malignant disease caused by abnormal white blood cells produced in bone marrow. An exacerbated and uncontrolled production of abnormal blood cells occurs, leading to a decreased production of healthy blood cells, promoting the rise of bleeding, several infections and severe anemia. In addition, leukemic cells can also spread to other organs such as spleen, brain, lymph nodes and other tissues.

Chromosomal translocations result in creation of gene fusion transcripts that aberrantly modulate various cellular processes. The table below lists translocations that are commonly associated with childhood and adult leukemias.

Translocation     Fusion Gene                 Diagnosis Frequency
t(8;21)(q22;q22)AML1-ETO (RUNX1-RUNX1T)Acute myeloid leukemia (AML)8%
t(1;19)(q23;p13)TCF3/PBX1Childhood precursor-B-ALL

Adult precursor-B-ALL

3-5% 3%
t(4;11)(q21;q23)MLL-AF4Childhood and adult precursor-B-ALL5%
t(12;21)(p13;q22)TEL-AML1Childhood precursor-B-ALL25%
Inv(16) (p13q22)CBFB-MYH11Acute myeloid leukemia (AML)8-9%
t(15;17)(q22;q21)PML-RARA bcr1, bcr2, bcr3Acute Promyelocytic Leukemia (APL)95%
t(9;22)(q34:q11)Minor BCR-ABL1 (p190)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

5% (Pediatrics)

5-50%(Adults)

t(9;22)(q34:q11)Micro BCR-ABL1 (p230)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

1-3%
Interstitial 4q12 deletionFIP1L1-PDGFRAEosinophilia associated myeloproliferative disorders

geneMAP™ BCR-ABL1 p230(μbcr) Detection Kit (BCR230-RT48)

FEATURES

  • Superior Analytical Sensitivity (Log4 Reduction)
  • Fast and Easy to Use with One Step RT-qPCR Technology
  • Accurate Relative Quantitation with Multiplex PCR (Fusion Transcripts/ABL1)
  • Compatible with FAM and VIC/HEX Dual Color Real-Time PCR Instruments
  • CE-IVD

Leukemia is one of the most common cancer types worldwide, presenting 250,000 cases annually. Leukemia is described as a malignant disease caused by abnormal white blood cells produced in bone marrow. An exacerbated and uncontrolled production of abnormal blood cells occurs, leading to a decreased production of healthy blood cells, promoting the rise of bleeding, several infections and severe anemia. In addition, leukemic cells can also spread to other organs such as spleen, brain, lymph nodes and other tissues.

Chromosomal translocations result in creation of gene fusion transcripts that aberrantly modulate various cellular processes. The table below lists translocations that are commonly associated with childhood and adult leukemias.

Translocation     Fusion Gene                 Diagnosis Frequency
t(8;21)(q22;q22)AML1-ETO (RUNX1-RUNX1T)Acute myeloid leukemia (AML)8%
t(1;19)(q23;p13)TCF3/PBX1Childhood precursor-B-ALL

Adult precursor-B-ALL

3-5% 3%
t(4;11)(q21;q23)MLL-AF4Childhood and adult precursor-B-ALL5%
t(12;21)(p13;q22)TEL-AML1Childhood precursor-B-ALL25%
Inv(16) (p13q22)CBFB-MYH11Acute myeloid leukemia (AML)8-9%
t(15;17)(q22;q21)PML-RARA bcr1, bcr2, bcr3Acute Promyelocytic Leukemia (APL)95%
t(9;22)(q34:q11)Minor BCR-ABL1 (p190)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

5% (Pediatrics)

5-50%(Adults)

t(9;22)(q34:q11)Micro BCR-ABL1 (p230)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

1-3%
Interstitial 4q12 deletionFIP1L1-PDGFRAEosinophilia associated myeloproliferative disorders

geneMAP™ RUNX1-RUNX1T1 t(8;21) Detection Kit (AML1-RT24)

FEATURES

  • Superior Analytical Sensitivity (Log4 Reduction)
  • Fast and Easy to Use with One Step RT-qPCR Technology
  • Accurate Relative Quantitation with Multiplex PCR (Fusion Transcripts/ABL1)
  • Compatible with FAM and VIC/HEX Dual Color Real-Time PCR Instruments
  • CE-IVD

Leukemia is one of the most common cancer types worldwide, presenting 250,000 cases annually. Leukemia is described as a malignant disease caused by abnormal white blood cells produced in bone marrow. An exacerbated and uncontrolled production of abnormal blood cells occurs, leading to a decreased production of healthy blood cells, promoting the rise of bleeding, several infections and severe anemia. In addition, leukemic cells can also spread to other organs such as spleen, brain, lymph nodes and other tissues.

Chromosomal translocations result in creation of gene fusion transcripts that aberrantly modulate various cellular processes. The table below lists translocations that are commonly associated with childhood and adult leukemias.

Translocation     Fusion Gene                 Diagnosis Frequency
t(8;21)(q22;q22)AML1-ETO (RUNX1-RUNX1T)Acute myeloid leukemia (AML)8%
t(1;19)(q23;p13)TCF3/PBX1Childhood precursor-B-ALL

Adult precursor-B-ALL

3-5% 3%
t(4;11)(q21;q23)MLL-AF4Childhood and adult precursor-B-ALL5%
t(12;21)(p13;q22)TEL-AML1Childhood precursor-B-ALL25%
Inv(16) (p13q22)CBFB-MYH11Acute myeloid leukemia (AML)8-9%
t(15;17)(q22;q21)PML-RARA bcr1, bcr2, bcr3Acute Promyelocytic Leukemia (APL)95%
t(9;22)(q34:q11)Minor BCR-ABL1 (p190)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

5% (Pediatrics)

5-50%(Adults)

t(9;22)(q34:q11)Micro BCR-ABL1 (p230)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

1-3%
Interstitial 4q12 deletionFIP1L1-PDGFRAEosinophilia associated myeloproliferative disorders

geneMAP™ TCF3/PBX1 t(1;19) Detection Kit (E2A-RT24)

FEATURES

  • Superior Analytical Sensitivity (Log4 Reduction)
  • Fast and Easy to Use with One Step RT-qPCR Technology
  • Accurate Relative Quantitation with Multiplex PCR (Fusion Transcripts/ABL1)
  • Compatible with FAM and VIC/HEX Dual Color Real-Time PCR Instruments
  • CE-IVD

Leukemia is one of the most common cancer types worldwide, presenting 250,000 cases annually. Leukemia is described as a malignant disease caused by abnormal white blood cells produced in bone marrow. An exacerbated and uncontrolled production of abnormal blood cells occurs, leading to a decreased production of healthy blood cells, promoting the rise of bleeding, several infections and severe anemia. In addition, leukemic cells can also spread to other organs such as spleen, brain, lymph nodes and other tissues.

Chromosomal translocations result in creation of gene fusion transcripts that aberrantly modulate various cellular processes. The table below lists translocations that are commonly associated with childhood and adult leukemias.

Translocation     Fusion Gene                 Diagnosis Frequency
t(8;21)(q22;q22)AML1-ETO (RUNX1-RUNX1T)Acute myeloid leukemia (AML)8%
t(1;19)(q23;p13)TCF3/PBX1Childhood precursor-B-ALL

Adult precursor-B-ALL

3-5% 3%
t(4;11)(q21;q23)MLL-AF4Childhood and adult precursor-B-ALL5%
t(12;21)(p13;q22)TEL-AML1Childhood precursor-B-ALL25%
Inv(16) (p13q22)CBFB-MYH11Acute myeloid leukemia (AML)8-9%
t(15;17)(q22;q21)PML-RARA bcr1, bcr2, bcr3Acute Promyelocytic Leukemia (APL)95%
t(9;22)(q34:q11)Minor BCR-ABL1 (p190)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

5% (Pediatrics)

5-50%(Adults)

t(9;22)(q34:q11)Micro BCR-ABL1 (p230)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

1-3%
Interstitial 4q12 deletionFIP1L1-PDGFRAEosinophilia associated myeloproliferative disorders

geneMAP™ MLL-AF4 t(4;11) Detection Kit (MLL-RT24)

FEATURES

  • Superior Analytical Sensitivity (Log4 Reduction)
  • Fast and Easy to Use with One Step RT-qPCR Technology
  • Accurate Relative Quantitation with Multiplex PCR (Fusion Transcripts/ABL1)
  • Compatible with FAM and VIC/HEX Dual Color Real-Time PCR Instruments
  • CE-IVD

Leukemia is one of the most common cancer types worldwide, presenting 250,000 cases annually. Leukemia is described as a malignant disease caused by abnormal white blood cells produced in bone marrow. An exacerbated and uncontrolled production of abnormal blood cells occurs, leading to a decreased production of healthy blood cells, promoting the rise of bleeding, several infections and severe anemia. In addition, leukemic cells can also spread to other organs such as spleen, brain, lymph nodes and other tissues.

Chromosomal translocations result in creation of gene fusion transcripts that aberrantly modulate various cellular processes. The table below lists translocations that are commonly associated with childhood and adult leukemias.

Translocation     Fusion Gene                 Diagnosis Frequency
t(8;21)(q22;q22)AML1-ETO (RUNX1-RUNX1T)Acute myeloid leukemia (AML)8%
t(1;19)(q23;p13)TCF3/PBX1Childhood precursor-B-ALL

Adult precursor-B-ALL

3-5% 3%
t(4;11)(q21;q23)MLL-AF4Childhood and adult precursor-B-ALL5%
t(12;21)(p13;q22)TEL-AML1Childhood precursor-B-ALL25%
Inv(16) (p13q22)CBFB-MYH11Acute myeloid leukemia (AML)8-9%
t(15;17)(q22;q21)PML-RARA bcr1, bcr2, bcr3Acute Promyelocytic Leukemia (APL)95%
t(9;22)(q34:q11)Minor BCR-ABL1 (p190)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

5% (Pediatrics)

5-50%(Adults)

t(9;22)(q34:q11)Micro BCR-ABL1 (p230)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

1-3%
Interstitial 4q12 deletionFIP1L1-PDGFRAEosinophilia associated myeloproliferative disorders

geneMAP™ TEL-AML1 t(12;21) Detection Kit (TEL-RT24)

FEATURES

  • Superior Analytical Sensitivity (Log4 Reduction)
  • Fast and Easy to Use with One Step RT-qPCR Technology
  • Accurate Relative Quantitation with Multiplex PCR (Fusion Transcripts/ABL1)
  • Compatible with FAM and VIC/HEX Dual Color Real-Time PCR Instruments
  • CE-IVD

Leukemia is one of the most common cancer types worldwide, presenting 250,000 cases annually. Leukemia is described as a malignant disease caused by abnormal white blood cells produced in bone marrow. An exacerbated and uncontrolled production of abnormal blood cells occurs, leading to a decreased production of healthy blood cells, promoting the rise of bleeding, several infections and severe anemia. In addition, leukemic cells can also spread to other organs such as spleen, brain, lymph nodes and other tissues.

Chromosomal translocations result in creation of gene fusion transcripts that aberrantly modulate various cellular processes. The table below lists translocations that are commonly associated with childhood and adult leukemias.

Translocation     Fusion Gene                 Diagnosis Frequency
t(8;21)(q22;q22)AML1-ETO (RUNX1-RUNX1T)Acute myeloid leukemia (AML)8%
t(1;19)(q23;p13)TCF3/PBX1Childhood precursor-B-ALL

Adult precursor-B-ALL

3-5% 3%
t(4;11)(q21;q23)MLL-AF4Childhood and adult precursor-B-ALL5%
t(12;21)(p13;q22)TEL-AML1Childhood precursor-B-ALL25%
Inv(16) (p13q22)CBFB-MYH11Acute myeloid leukemia (AML)8-9%
t(15;17)(q22;q21)PML-RARA bcr1, bcr2, bcr3Acute Promyelocytic Leukemia (APL)95%
t(9;22)(q34:q11)Minor BCR-ABL1 (p190)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

5% (Pediatrics)

5-50%(Adults)

t(9;22)(q34:q11)Micro BCR-ABL1 (p230)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

1-3%
Interstitial 4q12 deletionFIP1L1-PDGFRAEosinophilia associated myeloproliferative disorders

geneMAP™ CBFB-MYH11 Inv(16) Detection Kit (CBF-RT24)

FEATURES

  • Superior Analytical Sensitivity (Log4 Reduction)
  • Fast and Easy to Use with One Step RT-qPCR Technology
  • Accurate Relative Quantitation with Multiplex PCR (Fusion Transcripts/ABL1)
  • Compatible with FAM and VIC/HEX Dual Color Real-Time PCR Instruments
  • CE-IVD

Leukemia is one of the most common cancer types worldwide, presenting 250,000 cases annually. Leukemia is described as a malignant disease caused by abnormal white blood cells produced in bone marrow. An exacerbated and uncontrolled production of abnormal blood cells occurs, leading to a decreased production of healthy blood cells, promoting the rise of bleeding, several infections and severe anemia. In addition, leukemic cells can also spread to other organs such as spleen, brain, lymph nodes and other tissues.

Chromosomal translocations result in creation of gene fusion transcripts that aberrantly modulate various cellular processes. The table below lists translocations that are commonly associated with childhood and adult leukemias.

Translocation     Fusion Gene                 Diagnosis Frequency
t(8;21)(q22;q22)AML1-ETO (RUNX1-RUNX1T)Acute myeloid leukemia (AML)8%
t(1;19)(q23;p13)TCF3/PBX1Childhood precursor-B-ALL

Adult precursor-B-ALL

3-5% 3%
t(4;11)(q21;q23)MLL-AF4Childhood and adult precursor-B-ALL5%
t(12;21)(p13;q22)TEL-AML1Childhood precursor-B-ALL25%
Inv(16) (p13q22)CBFB-MYH11Acute myeloid leukemia (AML)8-9%
t(15;17)(q22;q21)PML-RARA bcr1, bcr2, bcr3Acute Promyelocytic Leukemia (APL)95%
t(9;22)(q34:q11)Minor BCR-ABL1 (p190)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

5% (Pediatrics)

5-50%(Adults)

t(9;22)(q34:q11)Micro BCR-ABL1 (p230)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

1-3%
Interstitial 4q12 deletionFIP1L1-PDGFRAEosinophilia associated myeloproliferative disorders

geneMAP™ PML-RARA t(15;17) bcr1&bcr2, bcr3 Detection Kit (PML-RT24)

FEATURES

  • Superior Analytical Sensitivity (Log4 Reduction)
  • Fast and Easy to Use with One Step RT-qPCR Technology
  • Accurate Relative Quantitation with Multiplex PCR (Fusion Transcripts/ABL1)
  • Compatible with FAM and VIC/HEX Dual Color Real-Time PCR Instruments
  • CE-IVD

Leukemia is one of the most common cancer types worldwide, presenting 250,000 cases annually. Leukemia is described as a malignant disease caused by abnormal white blood cells produced in bone marrow. An exacerbated and uncontrolled production of abnormal blood cells occurs, leading to a decreased production of healthy blood cells, promoting the rise of bleeding, several infections and severe anemia. In addition, leukemic cells can also spread to other organs such as spleen, brain, lymph nodes and other tissues.

Chromosomal translocations result in creation of gene fusion transcripts that aberrantly modulate various cellular processes. The table below lists translocations that are commonly associated with childhood and adult leukemias.

Translocation     Fusion Gene                 Diagnosis Frequency
t(8;21)(q22;q22)AML1-ETO (RUNX1-RUNX1T)Acute myeloid leukemia (AML)8%
t(1;19)(q23;p13)TCF3/PBX1Childhood precursor-B-ALL

Adult precursor-B-ALL

3-5% 3%
t(4;11)(q21;q23)MLL-AF4Childhood and adult precursor-B-ALL5%
t(12;21)(p13;q22)TEL-AML1Childhood precursor-B-ALL25%
Inv(16) (p13q22)CBFB-MYH11Acute myeloid leukemia (AML)8-9%
t(15;17)(q22;q21)PML-RARA bcr1, bcr2, bcr3Acute Promyelocytic Leukemia (APL)95%
t(9;22)(q34:q11)Minor BCR-ABL1 (p190)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

5% (Pediatrics)

5-50%(Adults)

t(9;22)(q34:q11)Micro BCR-ABL1 (p230)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

1-3%
Interstitial 4q12 deletionFIP1L1-PDGFRAEosinophilia associated myeloproliferative disorders

geneMAP™ FIP1L1-PDGFRA Detection Kit (FIP1-RT24)

FEATURES

  • Superior Analytical Sensitivity (Log4 Reduction)
  • Fast and Easy to Use with One Step RT-qPCR Technology
  • Accurate Relative Quantitation with Multiplex PCR (Fusion Transcripts/ABL1)
  • Compatible with FAM and VIC/HEX Dual Color Real-Time PCR Instruments
  • CE-IVD

Leukemia is one of the most common cancer types worldwide, presenting 250,000 cases annually. Leukemia is described as a malignant disease caused by abnormal white blood cells produced in bone marrow. An exacerbated and uncontrolled production of abnormal blood cells occurs, leading to a decreased production of healthy blood cells, promoting the rise of bleeding, several infections and severe anemia. In addition, leukemic cells can also spread to other organs such as spleen, brain, lymph nodes and other tissues.

Chromosomal translocations result in creation of gene fusion transcripts that aberrantly modulate various cellular processes. The table below lists translocations that are commonly associated with childhood and adult leukemias.

Translocation     Fusion Gene                 Diagnosis Frequency
t(8;21)(q22;q22)AML1-ETO (RUNX1-RUNX1T)Acute myeloid leukemia (AML)8%
t(1;19)(q23;p13)TCF3/PBX1Childhood precursor-B-ALL

Adult precursor-B-ALL

3-5% 3%
t(4;11)(q21;q23)MLL-AF4Childhood and adult precursor-B-ALL5%
t(12;21)(p13;q22)TEL-AML1Childhood precursor-B-ALL25%
Inv(16) (p13q22)CBFB-MYH11Acute myeloid leukemia (AML)8-9%
t(15;17)(q22;q21)PML-RARA bcr1, bcr2, bcr3Acute Promyelocytic Leukemia (APL)95%
t(9;22)(q34:q11)Minor BCR-ABL1 (p190)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

5% (Pediatrics)

5-50%(Adults)

t(9;22)(q34:q11)Micro BCR-ABL1 (p230)Acute Lymphoblastic Leukaemia (ALL)

or Chronic Myeloid Leukemia (CML)

1-3%
Interstitial 4q12 deletionFIP1L1-PDGFRAEosinophilia associated myeloproliferative disorders

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