geneMAP™ c-KIT D816V Mutation Detection Kit (CKT-RT25)
- Superior Analytical Sensitivity and specificity with Allele Specific PCR
- Fast and Easy to Use with Multiplex Realtime PCR Technology
- Compatible with FAM, VIC/HEX two Colors Real-Time PCR Instruments
This test is used for qualitative detection of the KIT c.2447A>T (D816V) mutation found in most adults (>80%) with systemic mastocytosis. Detection of the KIT D816V mutation can aid in diagnosis of systemic mastocytosis and guide choice of therapy since it is associated with resistance to imatinib mesylate. The KIT D816V mutation also occurs in some cases of acute myelogenous leukemia and seminoma.