geneMAP™BCR-ABL1 P210 (Mbcr) IS-MMR Detection Kit (BCR210-RT48)

Chronic myeloid leukemia (CML) is a slowly-progressing cancer characterized by the clonal myeloproliferative expansion of pluripotent hematopoietic stem cells resulting from acquisition of the fusion oncogene BCR-ABL1.

geneMAP™ Leukemia Kits

The Genmark Leukemia assay offers a very simple procedure for testing the most relevant mutations implicated

geneMAP™ BCR-ABL1 (p190, p210, p230) Screening Kit (BCRSCR-RT48)

BCR-ABL1 translocation can be observed in myeloproliferative neoplasms, acute leukemia of ambiguous lineage and precursor lymphoid neoplasms class as chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).

geneMAP™ JAK2 V617F Mutation Detection Kit (JK14-RT50)

Somatic mutation of the JAK2 gene (JAK2 p.V617F) can be detected in a variable proportion of patients with myeloproliferative neoplasms.

geneMAP™ MPL W515A/L/K/R Mutation Detection Kit (MPL-RT25)

Myeloproliferative Leukemia Virus (MPL) appears distinctly associated with polycythemia vera (PV), essential thrombocythemia (ET) and Primary myelofibrosis (PMF).

geneMAP™ CALR Mutation Screening Kit (CALR-RT25)

The calcium-binding endoplasmic reticulin chaperone protein, calreticulin (CALR), is somatically mutated in approximately 70% of patients with JAK2-negative essential thrombocythemia (ET) and 60% to 88% of patients with JAK2-negative primary myelofibrosis (PMF).

geneMAP™ JAK2 Exon 12 Mutation Screening Kit (JK12-RT50)

Mutations within exon 12 of the JAK2 gene occur in most cases of JAK2 V617F-mutation negative polycythemia vera.

geneMAP™ NPM1 (mutA,B,C&D) Mutation Detection Kit (NPM-RT25)

Nucleophosmin-1 (NPM1) mutations represent the most frequent gene alteration in acute myeloid leukemia (AML).

geneMAP™ FLT3 ITD/D835Y Mutation Detection Kit (FLT3-FA25)

Mutation of the fms-like tyrosine kinase 3 gene consisting of internal tandem duplication (FLT3-ITD), which is one of the most frequent genetic alterations, occurs in 15–35% of adults with acute myeloid leukemia (AML).

geneMAP™ FLT3 D835Y Mutation Detection Kit (FLT3-RT25)

FLT3 is mutated in 11.3% of acute myeloid leukemia patients with FLT3 D835Y present in 1.28% of all acute myeloid leukemia patients.

geneMAP™ c-KIT D816V Mutation Detection Kit (CKT-RT25)

This test is used for qualitative detection of the KIT c.2447A>T (D816V) mutation found in most adults (>80%) with systemic mastocytosis.

geneMAP™ WT1 Expression Analysis Kit (WT1-RT24)

WT1 is an important regulatory molecule involved in cell growth and development.

geneMAP™ PD-L1 Expression Analysis Kit (PDL-RT24)

So far most clinical trials have demonstrated superior efficacy of immunotherapy in advanced NSCLC, and shown a strong predictive association between PD-L1 expression levels and clinical efficacy endpoints such as overall survival, progression free survival, objective response rate.

geneMAP™ HER2 Expression Analysis Kit (HER-RT24)

The human epidermal growth factor receptor 2 gene (HER2, also known as erbB2) has been regarded a critical factor for diagnosis and effective treatment of breast cancer patients.

geneMAP™ MGMT Methylation Analysis Kit (MGM-RT50)

The MGMT Promoter Methylation Detection Kit is a methylation-specific Realtime PCR (MSP) test designed to detect and quantification O (6) -methylguanine-DNA methyltransferase (MGMT) promoter hypermethylation status in genomic DNA of glioblastoma multiform (GBM) tumors.

geneMAP™ MLH1 Methylation Analysis Kit (MLH1-RT50)

Lynch syndrome is an autosomal dominant, inherited cancer syndrome due to a germline mutation in a gene controlling DNA mismatch repair (MMR), such as MLH1, MSH2, MSH6 or PMS2.

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